Long Term Use of Antibiotics for Rosacea

Self-Experimenting Scientist Receives uBiome Grant to Investigate Consequences of Long-Term Antibiotic Use for Skin Conditions

uBiome, the leader in microbial genomics, has awarded a scientific grant to Dr. Eon Rios of Stanford University School of Medicine, supporting an investigation into how long-term use of oral antibiotics for skin conditions affects the gut microbiome.

San Francisco, CA,  January 11, 2017

Microbial genomics leader uBiome, is awarding an ongoing series of in-kind scientific grants to ground-breaking microbiome studies. Its most recent microbiome impact grant award has been made to Dr. Eon Rios of Stanford University School of Medicine, who will study the effect of long-term use of oral antibiotics, prescribed for skin conditions, on the gut microbiome.

Approximately 65 million Americans – around one-in-five – suffer from skin conditions such as acne and rosacea, and the first-line treatment for many of these patients with severe disease is the prescription of long-term oral antibiotics. Dr. Rios will explore the effects that these have on the gut microbiome.

His study will analyze patients’ microbiomes before, during, and after exposure to antibiotics. Among other goals, Dr. Rios hopes that his research will reveal whether the long-term use of oral antibiotics for skin conditions might influence the risk of developing other diseases later in life. Dr. Rios hypothesizes that chronic oral antibiotic use will induce permanent shifts in the gut microbiome in some patients, even after the medications have been discontinued.

Dr. Rios is a Physician-Scientist at Stanford University School of Medicine and also works as a dermatologist at Santa Clara Valley Medical Center. He was awarded his MD and PhD in the study of Immunology by Stanford University School of Medicine, and he received his BS in Neurobiology and Behavior from the University of California, Davis. He is a Fellow of the American Academy of Dermatology and received a Physician Scientist Career Development Award from the Dermatology Foundation in 2014.

What is the Microbiome?

antibiotics for rosacea

Dr. Eon Rios

The microbiome is the collective term for the ecosystem of trillions of microorganisms that live in and on the human body. Many of these microorganisms play crucial roles in supporting life. For example, gut bacteria aid digestion and enable the synthesis of vitamins. Pathogenic bacteria, however, can be associated with a range of conditions. In the case of the oral microbiome, these can include upper oral and esophageal cancers, cardiovascular diseases, and inflammatory bowel diseases.

uBiome employs next generation high-throughput DNA sequencing technology to generate detailed analyses of the human microbiome. The company is perhaps best known for its work on the gut microbiome, but uBiome also provides microbiome testing for four other sites on the human body: mouth, nose, genitals, and skin. The company has recently launched SmartGut™, the world’s first sequencing-based clinical microbiome test – a doctor-ordered, insurance-reimbursable test processed in its CAP-accredited lab – that is indicated for patients with chronic bowel issues.

Award winner Dr. Eon Rios, Physician-Scientist at Stanford University School of Medicine, says: “While it’s true that antibiotics can make a profound contribution to patient outcomes, it’s also clear that their overuse is having a significant negative impact. We also don’t really understand why taking an oral antibiotic can improve skin conditions such as acne and rosacea.

Are changes in the microbiome a potential mechanism? In addition, we need to better understand the implications of having individuals take oral antibiotics for skin conditions over months and some time years. Are we fixing one problem only to cause other serious health consequences further down the line? uBiome has tremendous capacity to process the many samples that will be collected for this longitudinal study. I’m grateful for their support.”

Dr. Zachary Apte, co-founder and CTO of uBiome adds: “Dr. Rios is investigating the exciting hypothesis that there is a connection between the gut microbiome and skin conditions. Currently, disorders such as acne and rosacea can be treated with oral antibiotics, understanding why this improves skin conditions could eventually lead to new treatment modalities. We are excited to support the research of Dr. Rios through this grant.”

Founded in 2012, uBiome is the world’s leading microbial genomics company. uBiome is funded by Y Combinator, Andreessen Horowitz, 8VC, and other leading investors.

uBiome’s mission is to explore important research questions about the microbiome and to develop accurate and reliable clinical tests based on the microbiome.

Acknowledgements:  PrWeb

Filed Under: Rosacea News

Ocular Rosacea Studies Report Findings

Two recent small studies on ocular rosacea yielded new findings that help in understanding its manifestations as well as the disease process.

Researchers at Kirikkale University in Turkey found that despite a high incidence of dry eye in individuals with rosacea, corneal and conjunctival sensitivity were not significantly different from the eyes of individuals without the disorder, the first time to their knowledge that a such a study has been conducted.(1)

The sensitivity of the cornea and the conjunctiva – the mucous membrane that covers the front of the eye and lines the insides of the eyelids – was measured in 55 people with rosacea and 37 healthy individuals with a device that mechanically stimulates the ocular surface with a nylon filament. The investigators also compared sensitivity with other standard ophthalmology examination results.

They noted that while the incidence of dry eye in people with rosacea is higher than normal, it was not associated with changes in ocular sensitivity, even though subjective symptoms were reported as slightly higher by rosacea patients responding to a questionnaire that assessed ocular irritation. The researchers suggested that although ocular rosacea may result in an increased number of nerves involved in pain transmission, coexisting dry eye reduces ocular surface sensitivity. They further noted that subjective symptoms may not correlate with the objective dry eye test results.

In addition, no correlation was found between sensitivity results and results of other standard ophthalmology examination measurements. The sensitivity findings may have implications for individuals undergoing cataract or LASIK surgery, they noted.

Ocular Rosacea Studies Help Define Disease Process

In another study at Ege University in Turkey, researchers found that 15 ocular rosacea patients had a low value for corneal hysteresis – a measurement of the cornea’s ability to regain its shape when pressure is applied – which has been linked to a greater risk of progression in patients with glaucoma. (2)  ocular rosacea studies

While glaucoma frequency in ocular rosacea patients was not previously investigated, the higher incidence of steroid use in rosacea and ocular rosacea patients might cause a tendency toward glaucoma, the investigators said, and a low value for corneal hysteresis may mean a faster rate of visual field loss in individuals with glaucoma.

Though results of small studies often appear obscure, they provide important information that helps physicians and researchers understand the biological and chemical underpinnings of a disease and how it may affect patients in a variety of circumstances.

References:
1. Örnek N, Karabulut AA, Örnek K, Onaran Z, Usta G. Corneal and conjunctival sensitivity in rosacea patients. Saudi Journal of Ophthalmology 2016;30:29-32.

2. Palamar M, Degirmenci C, Ertam I, Yagci A. Ocular response analyser measurements and central corneal thickness in ocular rosacea patients. International Ophthalmology DOI 10.1007/s10792-016-
0218-3.

Filed Under: Rosacea News

Soolantra Cream Promises Relief for Rosacea Sufferers

Breaking News: Soolantra Cream from NineMSN News:

There’s new hope for sufferers of the common skin disorder rosacea, with the greenlighting of a new cream that promises to offer much-needed relief.

The medication, known as Soolantra, is already showing promising results for those diagnosed with the non-contagious inflammatory skin condition.

Nathan Ponchard, 42, said he has tried all manner of treatments, from laser therapy, to pills and gel, in a bid to conquer his lifelong symptoms.

He said that after trying Soolantra, he has noticed a drastic improvement.

“I haven’t noticed not one single piece of dryness the whole time I’ve been on it, which is great, in combination with the fact that the redness isn’t as bad as it was before,” Mr Ponchard told 9NEWS.

“Mine’s not completely fixed but it’s definitely on its way to being, I dunno, normal.”

Soolantra has just been approved for use in Australia.

soolantra cream for rosacea

Dermatologist Dr John Sullivan says that unlike a lot of products marketed towards rosacea sufferers, the cream doesn’t irritate the skin and exacerbate symptoms.

A single tube of cream is expected to last patients about six weeks, and retails for between $50 to $55 dollars.

The government has no immediate plans to list Soolantra on the Pharmaceutical Benefits Scheme.

More than a million Australians are estimated to suffer from rosacea.

The condition typically sets in after adolescence, with many cases often going undiagnosed.

More information about Soolantra can be found here. 

© ninemsn 2016

Filed Under: Rosacea News

Finacea Foam for Rosacea: FDA Approval

We have just received news that the FDA has approved a new product that targets Acne Rosacea (papulopustular). It contains 15{950de5e870313faf4c5db3a7d190801ab62f662c92458036dbe5490915c0acf5} Azaelic Acid and is called Finacea Foam.

Here is the news transcript:

FDA Approves Bayer’s Finacea (azelaic acid) Foam, 15{950de5e870313faf4c5db3a7d190801ab62f662c92458036dbe5490915c0acf5} for the Topical Treatment of the Inflammatory Papules and Pustules of Mild to Moderate Rosacea

WHIPPANY, N.J., July 31, 2015 /PRNewswire/ — Bayer HealthCare today announced that the U.S. Food and Drug Administration (FDA) has approved Finacea (azelaic acid) Foam, 15{950de5e870313faf4c5db3a7d190801ab62f662c92458036dbe5490915c0acf5} for the topical treatment of the inflammatory papules and pustules of mild to moderate rosacea.

The approval is based on results from two pivotal clinical trials examining the efficacy and safety of Finacea Foam compared to its foam vehicle (without the drug azelaic acid) in the topical treatment of papulopustular rosacea.

Papulopustular rosacea is a skin disease causing inflammatory lesions (papules and pustules) on the nose, cheeks, chin and forehead.

The product uses “foamix technology” from Foamix Pharmaceuticals, who also manufacture acne products. So it is the result of a joint venture between Bayer HealthCare and Foamix Pharmaceuticals.

Here are the active ingredients in Finacea Foam:

benzoic acid, cetostearyl alcohol, dimethyl isosorbide, medium-chain triglycerides, methylcellulose, mono- and di-glycerides, polyoxyl 40 stearate, polysorbate 80, propylene glycol, purified water, sodium hydroxide, and xanthan gum.

Research Trials Were Promising

Here is some further information about Finacea Foam research and testing, from Skin and Allergy News.

Investigational Azelaic Acid Foam Quells Rosacea

FROM THE ANNUAL CONGRESS OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Medical Dermatology

By: BRUCE JANCIN, Skin & Allergy News Digital Network

LISBON – Physicians may soon have a new option for the treatment of papulopustular rosacea in the form of 15{950de5e870313faf4c5db3a7d190801ab62f662c92458036dbe5490915c0acf5} azelaic acid foam.

The 15{950de5e870313faf4c5db3a7d190801ab62f662c92458036dbe5490915c0acf5} foam is an extension of an existing product line which includes 15{950de5e870313faf4c5db3a7d190801ab62f662c92458036dbe5490915c0acf5} azelaic acid gel as an approved topical therapy for mild to moderate rosacea, Dr. Blanka Havlickova explained at the annual congress of the European Academy of Dermatology and Venereology

Major Finding: In all, 43{950de5e870313faf4c5db3a7d190801ab62f662c92458036dbe5490915c0acf5} of patients with papulopustular rosacea were rated as clear or as having minimal residual disease after 12 weeks of twice-daily, topical, 15{950de5e870313faf4c5db3a7d190801ab62f662c92458036dbe5490915c0acf5} azelaic acid foam therapy.

Data Source: A double-blind, vehicle-controlled, randomized clinical trial of 401 patients with mild to moderate papulopustular rosacea who were randomized to 12 weeks of twice-daily, self-applied azelaic acid foam or vehicle.

Disclosures: The trial was funded by Intendis, which is developing the investigational agent.

 

Filed Under: Rosacea News

New Rosacea Gel Approved by the FDA

On 27 August, 2013 it was reported in medicinenet.com that a new topical gel had been approved by the FDA, giving hope to millions of rosacea sufferers. The name of the new product is Mirvaso, containing the active ingredient, brimonodine tartrate. The rosacea gel is being manufactured by Galderma Laboratories, of Fort Worth, Texas and was approved following successful clinical trials with more than 550 patients.

Dr Mark Jackson of the University of Louisville, Kentucky, stated that the introduction of this new rosacea gel “marks a turning point in rosacea treatment.” Until now, physicians were only able to treat the bumps and pus filled pimply symptoms of rosacea while the facial redness that is its hallmark could only be treated with laser therapy. But this drug promises to provide a solution to the embarrassing red complexion that rosacea sufferers experience.

Rosacea is a chronic condition involving inflamed vascular vessels which among those who have it are closer to the surface of the face than they are with most people. Its cause is still unknown and since it is not life threatening, treatment options from the medical profession have been limited. Typical symptoms include a red flushed appearance on the cheeks and across the nose. Some sufferers experience pimply sores which are often mistaken for adult acne. In its more severe stages, it can produce a bulbous red nose with hardened scar tissue. Numerous rosacea triggers have been identified, including certain foods and beverages, changing weather conditions and emotional stress.

The approval of Mirvaso was also given the go ahead by the NHS in Britain and reported in the Daily Mail on 17 April 2014. Mirvaso’s effectiveness lies in its ability to restrict bloodflow to the upper layers of the skin. It is a clear gel which should be applied to the affected areas in pea sized amounts. It works within half an hour and is also effective for up to 12 hours. In the image below, you can see the difference this rosacea gel makes within just a few hours after application.

rosacea gelRosacea is often discounted as rosy cheeks or blushing – and other symptoms are sometimes confused with acne or other health related conditions. Either way, it is embarrassing for the person experiencing it and can leave the sufferer with psychological and self-esteem problems. Reports have even been received of sufferers committing suicide. Apparently the active ingredient, briminodine tartrate, has been safely used for some time in eye drops.

If you’ve been diagnosed with rosacea and you’re not into pharmaceutical solutions like the rosacea gel outlined in the above article, there are a number of natural remedies which you may like to consider. We explore these on other Rosacea-Skin-Care.com pages.

Filed Under: Rosacea News, ROSACEA PRODUCTS

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